' 
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.9
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
8
Folic Acid reduces IBS-related pain
Folic acid attenuates chronic visceral pain by reducing clostridiales abundance and hydrogen sulfide production.
Study shows promising treatment effects
We investigated the effects of Folic Acid (FA) on chronic visceral pain linked to Irritable Bowel Syndrome (IBS). Chronic visceral hyperalgesia (pain sensitivity) was induced in rats through neonatal colonic inflammation, enabling us to examine how FA might alleviate this condition.
Our findings indicated that patients with IBS had a higher diversity of intestinal bacteria, particularly those that produce hydrogen sulfide—a gas that has been connected to pain. We noted a significant correlation between the levels of hydrogen sulfide and the severity of visceral pain in these patients.
Interestingly, we found that the levels of Folic Acid were notably lower in the blood of IBS patients compared to those without IBS. Subsequent supplementation with FA showed promise, reducing chronic visceral pain in the rats and normalizing the abnormal increase in gas production. We also observed that this treatment minimized synaptic responses in the spinal neurons associated with visceral pain.
Overall, our research suggests that Folic Acid can play an important role in reducing chronic pain associated with IBS by lowering hydrogen sulfide production in the gut.
Our findings indicated that patients with IBS had a higher diversity of intestinal bacteria, particularly those that produce hydrogen sulfide—a gas that has been connected to pain. We noted a significant correlation between the levels of hydrogen sulfide and the severity of visceral pain in these patients.
Interestingly, we found that the levels of Folic Acid were notably lower in the blood of IBS patients compared to those without IBS. Subsequent supplementation with FA showed promise, reducing chronic visceral pain in the rats and normalizing the abnormal increase in gas production. We also observed that this treatment minimized synaptic responses in the spinal neurons associated with visceral pain.
Overall, our research suggests that Folic Acid can play an important role in reducing chronic pain associated with IBS by lowering hydrogen sulfide production in the gut.
Read More
Most Useful Reviews
9.5
Supports health benefits
I take folate even when not planning a pregnancy. It’s helped my health immensely and might have reduced the risk of hereditary diseases. I've noticed an improvement in my restless legs syndrome, which is likely linked to my nerves and blood vessels. The attacks have lessened since I started taking methylfolate, and I hope they won't return after I stop. This is a helpful vitamin, especially for treating irritable bowel syndrome.
Read More
6
Digestive issues worsened
My bowel movements worsened while taking this medication, likely due to exceeding the intake limit with another multivitamin. After I stopped taking it, my bowel movements improved. I suspect the excessive intake affected my digestive health, especially as I was also managing irritable bowel syndrome at the time.
Read More
5
Essential vitamin benefits
Folic acid is a synthetic variant of vitamin B9 that the body must convert into its active form. Many people are deficient in folate from food sources like leafy greens. Vitamin B9 is essential for DNA formation, fetal development, and reducing atherosclerosis risk. I take it to support my health, though I often worry about potential deficiencies due to poor diet or medication. Its contribution to treating my irritable bowel syndrome has been significant.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
Folic Acid reduces IBS-related pain
Folic acid attenuates chronic visceral pain by reducing clostridiales abundance and hydrogen sulfide production.
Study shows promising treatment effects
We investigated the effects of Folic Acid (FA) on chronic visceral pain linked to Irritable Bowel Syndrome (IBS). Chronic visceral hyperalgesia (pain sensitivity) was induced in rats through neonatal colonic inflammation, enabling us to examine how FA might alleviate this condition.
Our findings indicated that patients with IBS had a higher diversity of intestinal bacteria, particularly those that produce hydrogen sulfide—a gas that has been connected to pain. We noted a significant correlation between the levels of hydrogen sulfide and the severity of visceral pain in these patients.
Interestingly, we found that the levels of Folic Acid were notably lower in the blood of IBS patients compared to those without IBS. Subsequent supplementation with FA showed promise, reducing chronic visceral pain in the rats and normalizing the abnormal increase in gas production. We also observed that this treatment minimized synaptic responses in the spinal neurons associated with visceral pain.
Overall, our research suggests that Folic Acid can play an important role in reducing chronic pain associated with IBS by lowering hydrogen sulfide production in the gut.
Our findings indicated that patients with IBS had a higher diversity of intestinal bacteria, particularly those that produce hydrogen sulfide—a gas that has been connected to pain. We noted a significant correlation between the levels of hydrogen sulfide and the severity of visceral pain in these patients.
Interestingly, we found that the levels of Folic Acid were notably lower in the blood of IBS patients compared to those without IBS. Subsequent supplementation with FA showed promise, reducing chronic visceral pain in the rats and normalizing the abnormal increase in gas production. We also observed that this treatment minimized synaptic responses in the spinal neurons associated with visceral pain.
Overall, our research suggests that Folic Acid can play an important role in reducing chronic pain associated with IBS by lowering hydrogen sulfide production in the gut.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Supports health benefits
I take folate even when not planning a pregnancy. It’s helped my health immensely and might have reduced the risk of hereditary diseases. I've noticed an improvement in my restless legs syndrome, which is likely linked to my nerves and blood vessels. The attacks have lessened since I started taking methylfolate, and I hope they won't return after I stop. This is a helpful vitamin, especially for treating irritable bowel syndrome.
Read More
6
Digestive issues worsened
My bowel movements worsened while taking this medication, likely due to exceeding the intake limit with another multivitamin. After I stopped taking it, my bowel movements improved. I suspect the excessive intake affected my digestive health, especially as I was also managing irritable bowel syndrome at the time.
Read More
5
Essential vitamin benefits
Folic acid is a synthetic variant of vitamin B9 that the body must convert into its active form. Many people are deficient in folate from food sources like leafy greens. Vitamin B9 is essential for DNA formation, fetal development, and reducing atherosclerosis risk. I take it to support my health, though I often worry about potential deficiencies due to poor diet or medication. Its contribution to treating my irritable bowel syndrome has been significant.
Read More
8.3
Enhanced digestive function
The quality of this folic acid supplement is excellent, and I feel revitalised since taking it. It supports my energy, nervous system, and bowel movements. I've had significant improvement with digestive issues and constipation. I recommend this for anyone dealing with irritable bowel syndrome.
Read More
7.5
Improved intestinal health
After using Jarrow Formulas Methylfolate with vitamin B12, I noticed significant improvement in my intestinal inflammation and a reduction in my irritable bowel syndrome symptoms. I believe this combination has been effective for my digestive health.
